It was the year 1964 when UPCA Chemical Society was founded by Artemio Cartano , Luisito Tolentino and Dario Sabularse. After ten years of being organized, the name of the society was autonomously changed to UPLB Chemical Society (ChemSoc).​

Being the first and foremost objective of the UPLB Chemical Society, academic excellence is accomplished by instilling in its members and promoting to other students better scholastic attitudes towards the sciences, through quiz contests and various other programs. The organization has annually sponsored the Chemistry16 (General Chemistry 1) Interlaboratory Quiz Contest, held every first semester and Chemistry Quiz Contest, held every second semester of the academic year.​

The UPLB Chemical Society has not only succeeded in sponsoring university-wide quiz contests but in holding a national one as well. KAPNAYAN, a triennial week-long nationwide Chemistry fair that has been participated in by almost a hundred schools from all parts of the country. It is one pride of the society that promotes enthusiasm for and awareness in the field of chemistry among the youth of different dialects. This year's event will be th 13th KAPNAYAN with the theme Chemistry in Health and Wellness: Equipping Young Minds for Inevitable Challenges".